| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-129 | |
| Phytochemical name or plant extracts | Brevilin A | |
| PMID | 32596596 | |
| Literature evidence | BA-9 and BA-10 could more effectively reduce cancer cell viability and induce DNA damage, cell-cycle arrest, and apoptosis when compared with BA. | |
| IUPAC name | [(1S,3aR,5R,5aR,8aR,9S,9aR)-1,5,8a-trimethyl-2,8-dioxo-3a,4,5,5a,9,9a-hexahydro-1H-azuleno[6,5-b]furan-9-yl] (Z)-2-methylbut-2-enoate | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene lactone | |
| Source of phytochemicals or plant Extracts | Centipeda minima | |
| Geographical availability | Amur, Andaman Is., Assam, Bangladesh, Borneo, Cambodia, China North-Central, China South-Central, China Southeast, East Himalaya, Fiji, Hainan, India, Inner Mongolia, Japan, Jawa, Khabarovsk, Korea, Laos, Lesser Sunda Is., Malaya, Manchuria, Myanmar, Nansei-shoto, Nepal, New Caledonia, New Guinea, New South Wales, New Zealand North, New Zealand South, Northern Territory, Pakistan, Philippines, Primorye, Qinghai, Queensland, Samoa, Society Is., South Australia, Sri Lanka, Taiwan, Thailand, Tibet, Tonga, Vanuatu, Victoria, Vietnam, Western Australia, Xinjiang | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | AKT, mTOR, STAT-3 | |
| Gene or Protein evidence | BA significantly downregulated the expression of Akt, mTOR, Stat3 and their phosphorylation, and thus inhibiting the activation of the Akt/mTOR and STAT3 signaling pathways. | |
| Target pathways | Akt/mTOR and STAT3 signaling pathways | |
| IC50 | At 24h, 48h, 72h 13.31 μM, 5.723 μM, 3.764 μM against MDA-MB-231 respectively 14.46 μM, 4.089 μM, 3.034 μM against MDA-MB-468 respectively 10.62 μM, 9.475 μM, and 6.478 μM against MCF-7 respectively | |
| Potency | The IC50 values of brevilin A in MCF7 were approximately twice that of MDA-MB-231 and MDA-MB-468 for 48 and 72 h treatments. | |
| Cell line/ mice model | MDA-MB-231, MDA-MB-468, MCF-7 | |
| Additional information | Furthermore, oral administration of BA at 25 or 50 mg/kg leads to significant inhibition of tumor growth and proliferation in tumor xenograft model mice. | |
| PubChem ID | 12302076 | |
| Additional PMIDs | 31843524 32606754 32596596 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:191968-1 | |
| Safety | NA |