| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-188 | |
| Phytochemical name or plant extracts | Brassica oleracea juice | |
| PMID | 15930460 | |
| Literature evidence | These results suggest that the edible part of Brassica oleracea contains substances that can markedly inhibit the growth of both ER+ and ER- human breast cancer cells, although through different mechanisms. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic or Aqueous extract | |
| Source of phytochemicals or plant Extracts | Brassica oleracea | |
| Geographical availability | France, Great Britain, Spain | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | CDK6, p27 | |
| Gene or Protein evidence | In fact, at the molecular level, juice selectively reduces the levels of CDK6 and increases the level of the CDK6 inhibitor p27 in ER+ cells. | |
| Target pathways | NA | |
| IC50 | 5.1 mL/L against MCF-7 | |
| Potency | These results suggest that the edible part of Brassica oleracea contains substances that can markedly inhibit the growth of both ER+ and ER- human breast cancer cells, although through different mechanisms. These results suggest that the widely available cruciferous vegetables are potential chemopreventive agents. | |
| Cell line/ mice model | MCF-7, BT-474, MDA-MB-231, BT-20 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 30657939 34707435 34099785 15930460 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:279435-1 | |
| Safety | NA |