| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1848 | |
| Phytochemical name or plant extracts | Boswellia thurifera extract | |
| PMID | 25237368 | |
| Literature evidence | The results of the current study show that gum methanol extract of Boswellia thurifera has probably anti-cancer effects and could induce P53 gene transcription and toxicity in the cultured breast cancer cell line. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Boswellia thurifera | |
| Geographical availability | Assam, India, West Himalaya | |
| Plant parts | Gum | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53 | |
| Gene or Protein evidence | The increase of P53 gene specific mRNA may be a mechanism of gum methanol extract induced cytotoxicity. | |
| Target pathways | NA | |
| IC50 | 80 µg/mL against MDA-MB-231 | |
| Potency | The IC50 of the extract against cancer cells was 80 µg/mL and had less cytotoxic effect in normal cells. The effect of the extract was dose dependent. Induction of P53 expression by extract was also significantly more in treated cancer cells than untreated cells. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | The results of the current study show that gum methanol extract of Boswellia thurifera has probably anti-cancer effects and could induce P53 gene transcription and toxicity in the cultured breast cancer cell line. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:127067-1 | |
| Safety | The IC50 of the extract against cancer cells was 80 µg/mL and had less cytotoxic effect in normal cells. |