| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1941 | |
| Phytochemical name or plant extracts | Boswellia frereana extract (BFE) | |
| PMID | 30314527 | |
| Literature evidence | The addition of the BFE extract quenched the HGF-enhanced migratory, angiogenic and invasive potential of these cells. Further study revealed that BFE inhibited c-Met receptor tyrosine kinase phosphorylation within these breast cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Boswellia frereana | |
| Geographical availability | Somalia | |
| Plant parts | Gum raisin | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | Our findings reveal that BFE was able to significantly suppress the influence of HGF in breast cancer cell motility and invasion in vitro, through the ability of BFE to reduce HGF/c-Met signalling events. | |
| IC50 | NA | |
| Potency | These results indicate that BFE could play a novel role in the treatment of breast cancer. The addition of the BFE extract quenched the HGF-enhanced migratory, angiogenic and invasive potential of these cells. Further study revealed that BFE inhibited c-Met receptor tyrosine kinase phosphorylation within these breast cancer cells. | |
| Cell line/ mice model | BT-549 and MDA-MB-231 | |
| Additional information | we report that BFE suppresses HGF-enhanced cell migration, adhesion, vessel formation and invasion of breast cancer cells in vitro through inhibition of HGF/c-Met signalling and reduction of c-Met receptor phosphorylation. | |
| PubChem ID | NA | |
| Additional PMIDs | 30314527 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:127043-1 | |
| Safety | NA |