| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-174 | |
| Phytochemical name or plant extracts | Blueberry extract | |
| PMID | 32602283 | |
| Literature evidence | CONCLUSION: This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Vaccinium corymbosum | |
| Geographical availability | Alabama, Connecticut, Delaware, Florida, Georgia, Illinois, Indiana, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Mississippi, Missouri, New Brunswick, New Hampshire, New Jersey, New York, North Carolina, Nova Scotia, Ohio, Oklahoma, Ontario, Pennsylvania, Québec, Rhode I., South Carolina, Tennessee, Texas, Vermont, Virginia, West Virginia | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Colon cancer, Kidney cancer, Lung cancer, Cervical cancer, Prostate cancer | |
| Target gene or protein | PTEN | |
| Gene or Protein evidence | Although sera of both diet groups had similar antioxidant capacity, 5% blueberry sera elicited higher nuclear PTEN accumulation in human MCF-10A mammary epithelial cells. Our studies identify developing mammary glands as early targets of blueberry-associated bioactive components, possibly through systemic effects on epithelial PTEN signaling. | |
| Target pathways | Epithelial PTEN signaling | |
| IC50 | 53.2 ± 0.2 mg/L against MDA-MB-231 | |
| Potency | This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro. | |
| Cell line/ mice model | CT26, HCT-116, MDA-MB-231, PC-3, HeLa, SN12C, NCI-H125, MCF-7 | |
| Additional information | Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells. This study showed that polyphenol enrichment of a blueberry preparation by fermentation increases its chemopreventive potential by protecting mice against tumor development, inhibiting the formation of cancer stem cells and reducing lung metastasis. | |
| PubChem ID | NA | |
| Additional PMIDs | 25763692 21880954 17147415 32602283 23144318 22219179 19932869 26762586 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:261823-2 | |
| Safety | NA |