| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-769 | |
| Phytochemical name or plant extracts | Blackberry extract | |
| PMID | 17147415 | |
| Literature evidence | The berry extracts were evaluated for their ability to inhibit the growth of human oral (KB, CAL-27), breast (MCF-7), colon (HT-29, HCT116), and prostate (LNCaP) tumor cell lines at concentrations ranging from 25 to 200 micro g/mL. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Phenolic constituents | |
| Source of phytochemicals or plant Extracts | Rubus fruticosus | |
| Geographical availability | Austria, Baltic States, Belarus, Belgium, Czechoslovakia, Denmark, France, Germany, Great Britain, Hungary, Ireland, Italy, Netherlands, Norway, Poland, Sweden, Switzerland, Ukraine, Yugoslavia | |
| Plant parts | Fruits Fruits | |
| Other cancers | Breast cancer, Oral cancer, Prostate cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 122 (IC50 values were calculated by nonlinear regression) | |
| Potency | The LC(50) of blackberry crude extract ranged from 0.4 to 9.4 mg/mL between assays and across all cell lines, whereas a semi-purified anthocyanin extract was not cytotoxic. | |
| Cell line/ mice model | MCF-7, KB, CAL-27, HT-29, HCT116, LNCaP | |
| Additional information | The berry extracts were also evaluated for their ability to stimulate apoptosis of the COX-2 expressing colon cancer cell line, HT-29. | |
| PubChem ID | NA | |
| Additional PMIDs | 18435529 19271318 27904404 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:736933-1 | |
| Safety | NA |