| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-237 | |
| Phytochemical name or plant extracts | Black cohosh extract | |
| PMID | 14758092 | |
| Literature evidence | Author information: (1)Herbert Irvign Comperhensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. le2012@Columbia.edu The purpose of this study was to determine whether black cohosh contains constituents that inhibit the growth of human breast cancer cells, and therefore might eventually be useful in the prevention or treatment of breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Hexane extract, Ethyl acetate extract, Aqueous extract | |
| Source of phytochemicals or plant Extracts | Black cohosh | |
| Geographical availability | Alabama, Arkansas, Connecticut, Delaware, District of Columbia, Georgia, Illinois, Indiana, Kentucky, Maryland, Massachusetts, Missouri, New Jersey, New York, North Carolina, Ohio, Ontario, Pennsylvania, South Carolina, Tennessee, Virginia, West Virginia | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 18 µg/ml against MDA-MB-453 35 µg/ml against MCF7 39 µg/ml against MDA-MB-231 | |
| Potency | The ethyl acetate fraction displayed the highest potency in two cell-based assays, growth inhibition and cell cycle analysis. This fraction inhibited growth of both the ER+ MCF7 and ER-MDA-MB-453 human breast cancer cell lines with IC50 values of about 20 and 10 micro g/ml, respectively. It also induced cell cycle arrest at G1 when tested at 30 micro g/ml and at G2/M at 60 micro g/ml in MCF7 cells. | |
| Cell line/ mice model | MDA-MB-453, MCF-7, MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 23408273 32053921 32823812 14758092 15816531 18001221 18592868 21231853 29969672 30858726 20347238 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:316204-2 | |
| Safety | NA |