| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1845 |
| Phytochemical name or plant extracts | Bisdemethylcurcumin |
| PMID | 25089037 |
| Literature evidence | Knowing that curcumin has been used as food to inhibit cancer activity, this study evaluated the efficacy of natural curcumins and curcumin analogs as HER2 inhibitors using in vitro and in silico studies. |
| IUPAC name | (1E,6E)-1,7-bis(3,4-dihydroxyphenyl)hepta-1,6-diene-3,5-dione |
| Phytochemicals’ class or type of plant extracts | Curcuminoid |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | NA |
| Plant parts | NA |
| Other cancers | Breast cancer |
| Target gene or protein | NA |
| Gene or Protein evidence | NA |
| Target pathways | NA |
| IC50 | NA |
| Potency | NA |
| Cell line/ mice model | SKBR-3, MCF-7 |
| Additional information | We found that bisdemethylcurcumin (BDC) was more potent than curcumin as an anti-inflammatory agent as indicated by suppression of TNF-induced NF-κB activation, more potent as an anti-proliferative agent, and more potent in inducing ROS. |
| PubChem ID | 5469425 |
| Additional PMIDs | 20138025 |
| Additional sources of information | NA |
| Safety | NA |