| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1209 |
| Phytochemical name or plant extracts | Bis(4-hydroxy-2H-chromen-2-one) coumarin (4HC) |
| PMID | 31704838 |
| Literature evidence | MCF-7 mammary cancer cell proliferation was significantly decreased within 24 h after treatment with 4HC at 50 ?M, while no effect was observed on the viability of MCF-10a non-cancerous mammary cells. |
| IUPAC name | 3-[(4-chlorophenyl)-(4-hydroxy-2-oxochromen-3-yl)methyl]-4-hydroxychromen-2-one |
| Phytochemicals’ class or type of plant extracts | Coumarin |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | NA |
| Plant parts | NA |
| Other cancers | Breast cancer |
| Target gene or protein | CYP19A1, Bcl-2, Bax, Caspase 3, |
| Gene or Protein evidence | Ours results revealeed that 4HC has also anti-aromatase potency by inducing down-regulation of CYP19A1 gene expression, which could lead to the cell cycle arrest and promotion of apoptosis observed in MCF-7 cancer cells. A significant down-regulation of Bcl-2 and an up-regulation of the Bax gene expressions after 4HC treatment reflect a decrease in the Bcl-2/Bax ratio which could result in the activation of the caspase apoptosis proteins. Furthermore, our results suggested that down-regulation of aromatase gene may be a potential mechanism responsible for 4HC-induced cell death, resulting in a decrease in Bcl-2, an increase in Bax, and caspase-3 gene expression. |
| Target pathways | NA |
| IC50 | NA |
| Potency | Moreover, 4HC has inhibitory effects on aromatase gene expression and promoting effects on apoptosis, in MCF-7 cells. |
| Cell line/ mice model | MCF-7 |
| Additional information | Based on the diverse biological activity reported by coumarin derivatives, the anti-tumor potential and pro-apoptotic activities of 4HC have been investigated in MCF-7 estrogen receptor-positive (ER+) breast cancer cells, a widely-used model system for the study of breast cancer |
| PubChem ID | 54678493 |
| Additional PMIDs | NA |
| Additional sources of information | NA |
| Safety | NA |