| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1343 | |
| Phytochemical name or plant extracts | Bilberry extract | |
| PMID | 20132040 | |
| Literature evidence | In this study, we investigated the antiproliferative effects of bilberry extract in relation to its ability to induce apoptosis and affect microtubule assembly and organization in MCF7 human breast cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Vaccinium myrtillus | |
| Geographical availability | Albania, Alberta, Altay, Amur, Arizona, Austria, Baltic States, Belarus, Belgium, British Columbia, Bulgaria, Buryatiya, Central European Rus, Chita, Colorado, Corse, Czechoslovakia, Denmark, East European Russia, Finland, France, Føroyar, Germany, Great Britain, Greece, Greenland, Hungary, Iceland, Idaho, Ireland, Irkutsk, Italy, Japan, Kazakhstan, Khabarovsk, Krasnoyarsk, Mongolia, Montana, Netherlands, Nevada, New Mexico, North Caucasus, North European Russi, Northwest European R, Norway, Oregon, Poland, Portugal, Romania, Spain, Sweden, Switzerland, Transcaucasus, Turkey, Tuva, Ukraine, Utah, Washington, West Siberia, Xinjiang, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 0.3-0.4 mg/mL against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 | |
| Additional information | We conclude that bilberry extract as ingested by humans, not just the purified anthocyanins it contains, inhibits proliferation of and induces apoptosis in breast cancer cells at its lowest effective concentrations via a mechanism that does not involve action on microtubules or on mitosis. We further conclude that at somewhat higher concentrations the extract modifies microtubule organization in cells and causes accumulation of cells at mitosis by a direct action on microtubules. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30006039-2 | |
| Safety | NA |