| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2008 | |
| Phytochemical name or plant extracts | Bikaverin | |
| PMID | 30965682 | |
| Literature evidence | By virtual screening of the ZINC database, we found that the natural compound bikaverin can fit well in the ATP binding site of the target enzyme CK2. | |
| IUPAC name | 7,10-dihydroxy-3,8-dimethoxy-1-methylbenzo[b]xanthene-6,11,12-trione | |
| Phytochemicals’ class or type of plant extracts | Organic heterotetracyclic compound | |
| Source of phytochemicals or plant Extracts | Fusarium oxysporum EPH2RAA endophytic in Ephedra fasciculata | |
| Geographical availability | Ephedra fasciculata - Arizona, California, Nevada, Utah | |
| Plant parts | EtOAc extract of the fungal strain Fusarium oxysporum EPH2RAA | |
| Other cancers | Breast cancer, Lung cancer | |
| Target gene or protein | CK2 | |
| Gene or Protein evidence | Finally, molecular dynamic studies were performed to clarify the ligand binding mode of bikaverin at the ATP binding site of CK2 and to identify the amino acids involved. | |
| Target pathways | NA | |
| IC50 | By further in vitro evaluation using CK2 holoenzyme, bikaverin turned to be a potent inhibitor with an IC50 value of 1.24 µM. | |
| Potency | Cell viability and cell proliferation were reduced dramatically after treatment with 10 µM bikaverin for 24 h | |
| Cell line/ mice model | MCF-7, A427, A431 | |
| Additional information | NA | |
| PubChem ID | 36433 | |
| Additional PMIDs | 17286429 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:383389-1 | |
| Safety | NA |