| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1176 | |
| Phytochemical name or plant extracts | Bigelovii A | |
| PMID | 22414316 | |
| Literature evidence | Two new nortriterpenoid saponins from Salicornia bigelovii Torr. and their cytotoxic activity. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid saponins | |
| Source of phytochemicals or plant Extracts | Salicornia bigelovii | |
| Geographical availability | Alabama, Bahamas, Belize, California, Cayman Is., Cuba, Dominican Republic, Florida, Georgia, Haiti, Leeward Is., Maine, Maryland, Massachusetts, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, New Jersey, New York, North Carolina, Puerto Rico, South Carolina, Texas, Turks-Caicos Is., Virginia | |
| Plant parts | Dried herbs | |
| Other cancers | Breast cancer, Liver cancer, Lung cancer | |
| Target gene or protein | Bcl-2, Cyclin D1, NF‑κB‑regulated gene products, Cyclin D1, COX‑2 | |
| Gene or Protein evidence | In addition to the effects on Bcl‑2 and Bcl‑xl, Bigelovii A also downregulated the expression of the NF‑κB‑regulated gene products, Cyclin D1 and cyclooxygenase‑2. | |
| Target pathways | NA | |
| IC50 | 78.08 μM against MCF-7 | |
| Potency | Primary bioassays showed that compounds 1 and 3 had significant cytotoxic activity against HL-60 (leukemia), MCF-7 (breast), HepG2 (liver) cell-line human cancer panel. Compound 1 is Bigelovii A | |
| Cell line/ mice model | MDA‑MB‑231, MDA‑MB‑468HL-60, MCF-7, HepG2, A549 | |
| Additional information | Bigelovii A exhibits potential antitumor activity and induces marked apoptosis and membrane permeabilisation in HL‑60 cells. Furthermore, Bigelovii A suppressed constitutive IκBα phosphorylation via inhibition of IκB kinase activity. | |
| PubChem ID | NA | |
| Additional PMIDs | 29901099 22414316 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:166494-1 | |
| Safety | NA |