| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-85 | |
| Phytochemical name or plant extracts | Betavulgarin | |
| PMID | 32630026 | |
| Literature evidence | These data suggest that betavulgarin inhibit the Stat3/Sox2 signaling pathway and induces BCSC death, indicating betavulgarin might be an anticancer agent against breast cancer cells and BCSCs. | |
| IUPAC name | 7-(2-hydroxyphenyl)-9-methoxy-[1,3]dioxolo[4,5-g]chromen-8-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Beta vulgaris | |
| Geographical availability | Albania, Algeria, Azores, Baleares, Belgium, Bulgaria, Canary Is., Corse, Cyprus, East Aegean Is., Egypt, France, Germany, Great Britain, Greece, Gulf States, India, Iran, Iraq, Ireland, Italy, Kriti, Krym, Kuwait, Lebanon-Syria, Libya, Morocco, Netherlands, North Caucasus, Oman, Pakistan, Palestine, Portugal, Sardegna, Saudi Arabia, Sicilia, Sinai, Spain, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Yemen, Yugoslavia | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | Stat3/Sox2 signaling pathway | |
| IC50 | NA | |
| Potency | Betavulgarin had an antiproliferative effect on the MDA-MB-231 and MCF-7 cells at ≥ 100 µM and 50 µM, after 24 hrs of treatment | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | Betavulgarin suppressed the proliferation, migration, colony formation, and mammosphere formation of breast cancer cells and reduced the size of the CD44+/CD24- subpopulation and the expression of the self-renewal-related genes, C-Myc, Nanog, and Oct4. This compound decreased the total level and phosphorylated nuclear level of signal transducer and activator of transcription 3 (Stat3) and reduced the mRNA and protein levels of sex determining region Y (SRY)-box 2 (SOX2), in mammospheres. | |
| PubChem ID | 442668 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:164505-1 | |
| Safety | NA |