| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-895 | |
| Phytochemical name or plant extracts | Beta-carotene | |
| PMID | 12703993 | |
| Literature evidence | Author information: (1)Department of Nutrition and Food Science, Nanjing Medical University, Nanjing, Jiangsu, PR China. zhli@njmu.edu.cn BACKGROUND & OBJECTIVE: This study was conducted to investigate the altered gene expression of MCF-7 cell before and after the treatment with beta-carotene using cDNA microarray and to investigate the mechanism which beta-carotene induce breast cancer cell apoptosis. | |
| IUPAC name | 1,3,3-trimethyl-2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyl-18-(2,6,6-trimethylcyclohexen-1-yl)octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohexene | |
| Phytochemicals’ class or type of plant extracts | Retinol | |
| Source of phytochemicals or plant Extracts | Daucus carrota | |
| Geographical availability | Afghanistan, Albania, Algeria, Austria, Azores, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Canary Is., Cape Verde, Central European Rus, China South-Central, China Southeast, Corse, Cyprus, Czechoslovakia, Denmark, East Aegean Is., East European Russia, Eritrea, Ethiopia, France, Germany, Great Britain, Greece, Hungary, Iran, Iraq, Ireland, Italy, Kazakhstan, Kirgizstan, Kriti, Krym, Lebanon-Syria, Libya, Madeira, Morocco, Nepal, Netherlands, North Caucasus, Northwest European R, Norway, Pakistan, Palestine, Poland, Portugal, Romania, Sardegna, Sicilia, South European Russi, Spain, Sweden, Switzerland, Tadzhikistan, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, West Himalaya, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Colorectal cancer, Prostate cancer, Lung cancer, Stomach cancer, Cervical cancer | |
| Target gene or protein | AF040958, AK001555, g41894, hshsp90r, U83857, AB014509, AF126028, AF053641, AF117386, AF050127,NM_012177, humtopi, AJ250915, U37547, U78798, NM_004849, NM_005346, AF004711, NM_006595, NM_001418, AB015051 | |
| Gene or Protein evidence | A total of 21 genes related to cell apoptosis, cell signal transduction, protein translation and immunity were expressed differently after the treatment of beta-carotene, which 3/21 were up-regulated (AF040958, AK001555,g41894),18/21 were down- regulated(hshsp90r,U83857,AB014509,AF126028,AF053641,AF117386,AF050127,NM_012177,humtopi,AJ250915,U37547,U78798,NM_004849,NM_005346,AF004711,NM_006595,NM_001418,AB015051) | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, MD-MB-231, HCT-116, AGS , NCI-H460 | |
| Additional information | Increased intake of phytoestrogens, dietary fiber, and beta-carotene as well as regular physical activity and normal body weight lower the risk of breast cancer." dietary but not supplemental beta-carotene showed a protective effect against lobular breast cancer | |
| PubChem ID | 5280489 | |
| Additional PMIDs | 17035395 11415946 15296074 16799981 16512551 16442644 18601560 29386969 30025374 2333016 9808643 10738129 25026723 12324304 14747688 11823595 12933630 11822759 12690908 12923330 12735498 12948282 15860436 16231317 16766775 20368945 17392146 18400726 19089916 19565333 19507173 20116235 20698054 21864361 3916204 26043666 3684176 2583858 2757918 3334944 3414656 2239767 1866314 2228305 2159434 1848533 2334913 33619019 8233982 8381678 1617118 8547538 8567108 8771571 8123493 8609642 8122048 9103304 9000614 9498489 9264275 9280184 9306075 9486460 10088626 10360338 10453174 10941247 11251982 11566646 11415491 12703993 15342450 16900085 2621291 1420852 1562989 8053747 9367061 10616263 10676554 10090300 10962881 10694779 16277432 11876489 24596385 30983210 8724218 10573560 11348397 12131659 15113052 10658528 1302568 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:841063-1 | |
| Safety | NA |