| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1585 | |
| Phytochemical name or plant extracts | Beta-Sitosterol | |
| PMID | 18338406 | |
| Literature evidence | SIT potently activated de novo CER synthesis in both MCF-7 and MDA-MB-231 cells by stimulating serine palmitoyltransferase activity, whereas TAM promoted CER accumulation in both cell types by inhibiting CER glycosylation. | |
| IUPAC name | (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | |
| Phytochemicals’ class or type of plant extracts | phytosterol | |
| Source of phytochemicals or plant Extracts | Styrax perkinsiae Gastrodia elata Blume Zanthoxylum nitidum Goniothalamus laoticus | |
| Geographical availability | Styrax perkinsiae - Assam, Bangladesh, China North-Central, China South-Central, China Southeast, East Himalaya, Myanmar, Nepal, Tibet Gastrodia elata Blume - Assam, China North-Central, China South-Central, China Southeast, East Himalaya, Inner Mongolia, Japan, Khabarovsk, Korea, Kuril Is., Manchuria, Nepal, Primorye, Sakhalin, Taiwan, Tibet Zanthoxylum nitidum - Assam, Bangladesh, Burundi, China North-Central, China South-Central, China Southeast, East Himalaya, Ethiopia, Hainan, India, Jawa, Kenya, Laos, Lesser Sunda Is., Madagascar, Malawi, Mauritius, Mozambique, Myanmar, Nansei-shoto, Nepal, Northern Provinces, Philippines, Rodrigues, Rwanda, Réunion, Sri Lanka, Sudan, Swaziland, Taiwan, Tanzania, Thailand, Tibet, Uganda, Vietnam, Zambia, Zaïre, Zimbabwe Goniothalamus laoticus - China South-Central, Laos, Thailand | |
| Plant parts | Seeds Rhizome Stem Flowers | |
| Other cancers | Breast cancer, Prostate cancer, Colon cancer, Lung cancer, Stomach cancer, Ovarian cancer, Leukemia | |
| Target gene or protein | Caspase 8, Caspase 9 | |
| Gene or Protein evidence | The results of the present study indicate that beta-sitosterol supplementation at 16 microM for 3 days to MDA-MB-231 cells induces 39% and 80% increases in the activities of caspases 8 and 9, respectively, compared to cholesterol supplemented cells or controls. | |
| Target pathways | These data suggest that the down regulation of cholesterol synthesis from mevalonate and stimulation of the MAPK pathway may play roles in the inhibition of MDA-MB-231 cell growth by beta-sitosterol. | |
| IC50 | NA | |
| Potency | These findings support the hypothesis that beta-sitosterol is an effective apoptosis-promoting agent and that incorporation of more phytosterols in the diet may serve a preventive measure for breast cancer. Cells grown in the presence of 16 microM beta-sitosterol or campesterol for 3 days exhibited a 70% and 6% reduction in cell growth, respectively, while cholesterol treatment had no effect on growth as compared to the control. | |
| Cell line/ mice model | HT29, MCF-7, PC3, MDA-MB-231 and U-87 MG | |
| Additional information | It is concluded that, among PS, beta-sitosterol may offer protection from breast cancer metastasis by inhibiting cell invasion of the BM, which may be mediated by its ability to limit the adhesive interaction of the tumor cell and the BM. | |
| PubChem ID | 222284 | |
| Additional PMIDs | 12579296 15640948 17350814 19833183 19815390 26473555 19048793 21615011 19573585 24459770 26246431 24689209 16448187 16899264 15924924 15261389 24066513 23738449 25026723 19768978 12667603 18338406 11962251 10762659 17084606 12946404 19471192 19551734 17973203 16206040 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:826893-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:635522-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:775897-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:73209-1 | |
| Safety | NA |