| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1243 | |
| Phytochemical name or plant extracts | Bergapten (Bg) | |
| PMID | 26459431 | |
| Literature evidence | In both cell lines, Bg blocked glycolysis and significantly decreased glucose-6-phosphate dehydrogenase (G6PDH) activity promoting glucose accumulation, modulated bioenergetic requirements altering the expression of oxidative phosphorylation (OXPHOS) complexes and ATP production, and induced a lipid-lowering effect since an increased lipase activity concomitantly to a reduction in triglyceride levels was observed. | |
| IUPAC name | 4-methoxyfuro[3,2-g]chromen-7-one | |
| Phytochemicals’ class or type of plant extracts | Coumarin | |
| Source of phytochemicals or plant Extracts | Ficus carica | |
| Geographical availability | Afghanistan, Cyprus, Greece, Iran, Iraq, Kriti, Lebanon-Syria, North Caucasus, Pakistan, Palestine, Tadzhikistan, Transcaucasus, Turkey, Turkmenistan, West Himalaya | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, PTEN | |
| Gene or Protein evidence | Evidence that bergapten, independently of its photoactivation, enhances p53 gene expression and induces apoptosis in human breast cancer cells. Our data indicate PTEN as a key target of Bergapten action in breast cancer cells for the induction of autophagy. | |
| Target pathways | PTEN is transcriptionally regulated by Bergapten through the involvement of p38MAPK/NF-Y, as evidenced by the use of p38MAPK inhibitor SB203580, site-direct mutagenesis of NF-Y element and NF-Y siRNA. | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231, MCF-7, ZR75 | |
| Additional information | Bg can be used in combination with other forms of targeted chemotherapy to improve cancer treatment outcomes. Bergapten is under investigation in clinical trial NCT00533195 (Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis). | |
| PubChem ID | 2355 | |
| Additional PMIDs | 26459431 26148846 19519316 31931162 30100743 29715541 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:852556-1 | |
| Safety | NA |