| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-260 | |
| Phytochemical name or plant extracts | Berberis vulgaris extract | |
| PMID | 25916942 | |
| Literature evidence | In this study we evaluated the biological activity of alcoholic and aqueous extracts from the fruit of Berberis vulgaris. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Alcoholic extract and aqueous extract | |
| Source of phytochemicals or plant Extracts | Berberis vulgaris | |
| Geographical availability | Albania, Algeria, Austria, Baltic States, Belarus, Belgium, Bulgaria, Central European Rus, Corse, Czechoslovakia, East European Russia, France, Germany, Greece, Hungary, Iran, Italy, Krym, Morocco, North Caucasus, Northwest European R, Poland, Romania, Sardegna, Sicilia, South European Russi, Spain, Switzerland, Transcaucasus, Turkey, Ukraine, Uzbekistan, Yugoslavia | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | Aqueous extract - 3 ± 0.08 mg/ml for 24h, 1.5 ± 0.04 mg/ml for 48h, 0.5 ± 0.02 mg/ml for 72h Alcoholic extract - 4 ± 0.05 mg/ml for 24h, 2 ± 0.03 mg/ml for 48h, 1 ± 0.07 mg/ml for 72h | |
| Potency | The IC50 values strongly indicated that the effective doses of alcoholic extracts of Berberis were lower compared to aqueous extracts after different incubation times | |
| Cell line/ mice model | MCF10-A, MCF-7 | |
| Additional information | Our results suggest that Berberis has potent antioxidant properties and cytotoxic effects that can induce apoptosis. | |
| PubChem ID | NA | |
| Additional PMIDs | 32093423 24007270 25916942 28558642 18389483 29805448 29796035 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:328527-2 | |
| Safety | NA |