| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1330 | |
| Phytochemical name or plant extracts | Bavachin | |
| PMID | 31814840 | |
| Literature evidence | Expression levels of ABCG2 and P-gp were not significantly downregulated by these flavonoids. | |
| IUPAC name | (2S)-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Psoralea corylifolia | |
| Geographical availability | Assam, Bangladesh, China South-Central, Djibouti, India, Iraq, Jawa, Laos, Malaya, Myanmar, Oman, Pakistan, Somalia, Sri Lanka, Vietnam, West Himalaya, Yemen | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer, Stomach cancer, Colon cancer | |
| Target gene or protein | ABCG2 | |
| Gene or Protein evidence | Flavonoids did not reduce mRNA expression of P-gp and ABCG2 after 72Â h treatment, except Candidone in EPG85.257RDB and Bavachinin in MCF7/MX cells. | |
| Target pathways | Reduces mRNA expression of P-gp and ABCG2 in MCF7/MX cells | |
| IC50 | NA | |
| Potency | IC10: 1773 ± 534 nM, 2406.4 ± 257.63 nM (MCF7/MX)) EC50 - 95.3 ± 2.6 µm (MCF-7) | |
| Cell line/ mice model | MCF-7/MX, EPG85.257RDB, HT-29, Caco-2, LLC-PK1, MCF-7 | |
| Additional information | Inhibits growth of Caco-2 and HT-29 cells, LLC-PK1 and MCF-7 cells, Displays antiproliferative activities in the aforementioned cell lines. Decreases the viability of MCF7/MX and EPG85.257RDB cells and significantly (p < 0.05) decreases IC50 of daunorubicin and mitoxantrone in MCF7/MX cells - possesses the potential of sensitizing MDR cells to mitoxantrone and daunorubicin. | |
| PubChem ID | 14236566 | |
| Additional PMIDs | 34564803 10443335 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:516049-1 | |
| Safety | NA |