| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1374 | |
| Phytochemical name or plant extracts | Bauhinia variegata extract | |
| PMID | 16257158 | |
| Literature evidence | These results show a significant chemopreventive and cytotoxic effect of ethanol extract of Bauhinia variegata against DEN induced liver tumor and human cancer cell lines. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Bauhinia variegata | |
| Geographical availability | Assam, Bangladesh, China South-Central, East Himalaya, India, Laos, Nepal, Pakistan, Panamá, Thailand, Vietnam | |
| Plant parts | Stem | |
| Other cancers | Breast cancer, Lung cancer, Prostate cancer, Ovarian cancer, Leukemia | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 12.10-14.20 µg/mL against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | DU-145, HOP-62, IGR-OV-1, MCF-7, and THP-1 | |
| Additional information | Effectively suppresses DEN induced liver tumor - decrease in DEN induced elevated levels of serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin, gamma glutamate transpeptidase (GGTP), lipid peroxidase (LPO), glutathione peroxidase (GPx) and glutathione S-transferase (GST). Shows pronounced cytotoxic effect against DU-145, HOP-62, IGR-OV-1, MCF-7, and THP-1 cell lines with 90-99% cell growth inhibitory activity (AQ fraction) , against MCF-7 and THP-1 cell lines (Ethyl acetate fraction) | |
| PubChem ID | NA | |
| Additional PMIDs | 31627372 35170677 16257158 24093108 18942841 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:481756-1 | |
| Safety | NA |