| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-503 | |
| Phytochemical name or plant extracts | Barbigerone | |
| PMID | 29368443 | |
| Literature evidence | These results revealed that BA might reverse P-gp mediated MDR through inhibition of ATPase activity, which indicated a novel use of BA as a potent candidate for cancer chemotherapy. | |
| IUPAC name | 8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)pyrano[2,3-f]chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Millettia ferruginea | |
| Geographical availability | Ethiopia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | P-gp ATPase | |
| Gene or Protein evidence | Furthermore, the results also revealed that BA did not affect P-gp, but alter P-gp ATPase activity. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | BA (0.5 μM) treatment showed strong potency to increase ADR cytotoxicity toward MCF-7/ADR cells. | |
| Cell line/ mice model | MCF-7/ADR | |
| Additional information | Intravenous administration of BA significantly increased anticancer efficacy of ADR to MCF-7/ADR xenograft model in nude mice. These results revealed that BA might reverse P-gp mediated MDR through inhibition of ATPase activity, which indicated a novel use of BA as a potent candidate for cancer chemotherapy. | |
| PubChem ID | 156793 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:507366-1 | |
| Safety | NA |