| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1157 | |
| Phytochemical name or plant extracts | Baneh gum | |
| PMID | 32184861 | |
| Literature evidence | In conclusion, Baneh gum (100 µg/mL) has a potential pro-apoptotic/anti-proliferative property against human breast cancer cells and its combination with doxorubicin in low doses may induce cell death effectively and be a potent modality to treat this type of cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Gum | |
| Source of phytochemicals or plant Extracts | Pistacia atlantica | |
| Geographical availability | Afghanistan, Algeria, Canary Is., Cyprus, East Aegean Is., Greece, Iran, Iraq, Krym, Lebanon-Syria, Libya, Morocco, North Caucasus, Pakistan, Palestine, Saudi Arabia, Sinai, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, West Himalaya | |
| Plant parts | Plant extract | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, Caspase 3 | |
| Gene or Protein evidence | The result showed that Baneh gum (100 µg/mL) significantly induced cell damage, activated caspase3, and increased P53 protein level. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | In conclusion, Baneh gum (100 µg/mL) has a potential pro-apoptotic/anti-proliferative property against human breast cancer cells and its combination with doxorubicin in low doses may induce cell death effectively and be a potent modality to treat this type of cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Furthermore, combination treatment of cells with Baneh gum (25 µg/mL) and doxorubicin (200 nM) produced a significant cytotoxic effect as compared to each drug alone. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:70236-1 | |
| Safety | NA |