| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-720 | |
| Phytochemical name or plant extracts | Baneh extract | |
| PMID | 21818667 | |
| Literature evidence | It is now widely accepted that dietary phytochemicals inhibit cancer progression and enhance the effects of conventional chemotherapy. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Pistacia atlantica | |
| Geographical availability | Afghanistan, Algeria, Canary Is., Cyprus, East Aegean Is., Greece, Iran, Iraq, Krym, Lebanon-Syria, Libya, Morocco, North Caucasus, Pakistan, Palestine, Saudi Arabia, Sinai, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, West Himalaya | |
| Plant parts | Fruits skin | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, PARP, Cyclin D1, CDK4 | |
| Gene or Protein evidence | Finally, molecular analysis of apoptosis by western blotting proved activation of caspase 3 followed by poly ADP ribose polymerase (PARP) cleavage more efficiently in Baneh than in Dox treated cancer cells. Taken together, our results establish that the antitumor activity of the pericarp extract of Baneh partly is mediated via cell cycle arrest and downregulation of cyclin D1 and cdk4 expression. | |
| Target pathways | NA | |
| IC50 | 1 mg/ml against T47D | |
| Potency | These findings indicate that Baneh extract contains phytochemicals which act as inhibitor of cell proliferation and inducer of apoptosis in human breast cancer T47D cells that makes it a potentially good candidate for new anticancer drug development. | |
| Cell line/ mice model | T47D | |
| Additional information | Analysis of Baneh-treated cells by flow cytometry and fluorescence microscopy indicated strong apoptosis induction and nuclear morphological alterations similar to or greater than Dox. | |
| PubChem ID | NA | |
| Additional PMIDs | 23351343 32184861 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:70236-1 | |
| Safety | NA |