| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1541 | |
| Phytochemical name or plant extracts | Balanophonin | |
| PMID | 29040842 | |
| Literature evidence | Neolignans 1-12 showed significant cytotoxic effects against various human cancer cell lines with IC50 values ranging from 0.16 to 18.62 μM. | |
| IUPAC name | (E)-3-[(2S,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]prop-2-enal | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Mappianthus iodoies, Cornus kousa, Eria bambusifolia | |
| Geographical availability | Mappianthus iodoies - China South-Central, China Southeast, Hainan, Vietnam Cornus kousa - China North-Central, China South-Central, China Southeast, East Himalaya, Inner Mongolia, Japan, Korea, Nansei-shoto, Taiwan Eria bambusifolia - Assam, China South-Central, China Southeast, East Himalaya, India, Laos, Myanmar, Thailand, Vietnam | |
| Plant parts | Leaves, stem, Fruits | |
| Other cancers | Breast cancer, Leukemia, Liver cancer, Lung cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 15.66 ± 0.12 µM against MCF-7 | |
| Potency | The cytotoxicities against several human cancer cell lines of 1-12 were also investigated, and found to be quite potent, which may be used as an explanation of the folk use of M. iodoies, which had been used to treat tumors in China. | |
| Cell line/ mice model | HL-60, SMMC-7721, A-549, MCF-7 and SW-480 | |
| Additional information | NA | |
| PubChem ID | 23252258 | |
| Additional PMIDs | 18704322 26795438 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:434429-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30115668-2 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:633510-1 | |
| Safety | NA |