| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2077 | |
| Phytochemical name or plant extracts | Baeckea frutescens extracts | |
| PMID | 31178918 | |
| Literature evidence | The identification of Baeckea frutescens and its possible role in selectively inhibiting glucose consumption in breast cancer cells defines a new role of natural product that can be utilised as an effective agent that regulates metabolic reprogramming in breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Baeckea frutescens | |
| Geographical availability | Borneo, Cambodia, China Southeast, Hainan, Jawa, Laos, Lesser Sunda Is., Malaya, Myanmar, New Guinea, New South Wales, Philippines, Queensland, Sulawesi, Sumatera, Thailand, Vietnam | |
| Plant parts | Branches | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 53 μg/ml against MCF-7 with 70% ethanol | |
| Potency | The identification of Baeckea frutescens and its possible role in selectively inhibiting glucose consumption in breast cancer cells defines a new role of natural product that can be utilised as an effective agent that regulates metabolic reprogramming in breast cancer. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, MCF-10A | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 34598696 | |
| Additional sources of information | NA | |
| Safety | The in vitro cytotoxicity of B. frutescens extracts was evaluated against MCF10A at three various concentrations: a concentration lower than IC50, the IC50 value, and a concentration higher than IC50. All B. frutescens extracts tested showed insignificant cytotoxic activity against the normal human breast cancer cells . This indicates the selective cytotoxic activity of B. frutescens towards cancer cells and not normal cells. |