| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-957 | |
| Phytochemical name or plant extracts | Azadirachta indica extract | |
| PMID | 24624140 | |
| Literature evidence | The present study was designed to gain insight into the antiproliferative activity of ethanolic neem leaves extract (ENLE) alone or in combination with cisplatin by cell viability assay on human breast (MCF-7) and cervical (HeLa) cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Azadirachta indica | |
| Geographical availability | Assam, Bangladesh, Borneo, Cambodia, Laos, Malaya, Maluku, Myanmar, New Guinea, Philippines, Sulawesi, Sumatera, Thailand, Vietnam | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer and Cervical cancer | |
| Target gene or protein | Bax, Cyclin D1, CYP 1A1, CYP 1A2 | |
| Gene or Protein evidence | ENLE significantly modulated the expression of bax, cyclin D1, and cytochrome P450 monooxygenases (CYP 1A1 and CYP 1A2) in a time-dependent manner in these cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The EC50 (effective concentration, the dose which reduces the viability of cells by 50%) of ENLE was found to be 350 μg/mL on MCF-7 cells and 175 μg/mL on HeLa cells after 72 and 48 h treatment, respectively. | |
| Cell line/ mice model | MCF-7, HeLa | |
| Additional information | Conclusively, these results emphasize the chemopreventive ability of neem alone or in combination with chemotherapeutic treatment to reduce the cytotoxic effects on normal cells, while potentiating their efficacy at lower doses. Thus, neem may be a prospective therapeutic agent to combat gynecological cancers. | |
| PubChem ID | NA | |
| Additional PMIDs | 32346344 23679992 25044585 28292015 23507990 35152903 24706622 24634075 24443427 29605257 21674442 31632020 30109187 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:924837-1 | |
| Safety | NA |