| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-923 | |
| Phytochemical name or plant extracts | Avicennia marina extract | |
| PMID | 27078842 | |
| Literature evidence | Polyphenol-rich Avicennia marina leaf extracts induce apoptosis in human breast and liver cancer cells and in a nude mouse xenograft model. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethyl acetate extract | |
| Source of phytochemicals or plant Extracts | Avicennia marina | |
| Geographical availability | Aldabra, Andaman Is., Bangladesh, Bismarck Archipelago, Borneo, Cape Provinces, China Southeast, Christmas I., Cocos (Keeling) Is., Comoros, Djibouti, Egypt, Eritrea, Gulf States, Hainan, India, Iran, Jawa, Kenya, KwaZulu-Natal, Lesser Sunda Is., Madagascar, Malaya, Maluku, Mozambique, Mozambique Channel I, Myanmar, Nansei-shoto, New Caledonia, New Guinea, New South Wales, New Zealand North, Nicobar Is., Norfolk Is., Northern Territory, Oman, Pakistan, Philippines, Queensland, Saudi Arabia, Seychelles, Sinai, Socotra, Solomon Is., Somalia, South Australia, Sri Lanka, Sudan, Sulawesi, Sumatera, Taiwan, Tanzania, Thailand, Victoria, Vietnam, Western Australia, Yemen | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | MMP2, MMP9, Cyclin B, Vimentin, snail | |
| Gene or Protein evidence | EtOAc extracts for 24 h decreased cell migration by downregulating protein expression of MMP2, MMP9, cyclin B, vimentin, and snail protein in MDA-MB-231 cells, indicating decreased breast cancer cell growth both in vivo and in vitro | |
| Target pathways | NA | |
| IC50 | 0.75, 0.85 μg/mL for AU565, BT483 respectively | |
| Potency | EtOAc extracts of A. marina leaves also suppressed xenograft MDA-MB-231 tumor growth in nude mice, suggesting that EtOAc extracts of A. marina leaves may provide a useful treatment for breast cancer. | |
| Cell line/ mice model | MDA-MB-231, AU565, BT483 | |
| Additional information | In summary, EtOAc extracts of A. marina leaves induce apoptosis and inhibit migration of breast and liver cancer cells. | |
| PubChem ID | NA | |
| Additional PMIDs | 34528536 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:861130-1 | |
| Safety | NA |