| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1719 | |
| Phytochemical name or plant extracts | Aurovertin B | |
| PMID | 32539922 | |
| Literature evidence | In this study, flow cytometry and DAPI staining analysis showed that aurovertin B treatment in human triple-negative breast cancer cell MDA-MB-231 could induce more apoptotic cells than taxol treatment group. | |
| IUPAC name | [(1S,3S,4S,5S,7R,8S)-7-ethyl-4-hydroxy-3-[(1E,3E,5E)-6-(4-methoxy-3-methyl-6-oxopyran-2-yl)hexa-1,3,5-trienyl]-1,5-dimethyl-2,6-dioxabicyclo[3.2.1]octan-8-yl] acetate | |
| Phytochemicals’ class or type of plant extracts | Macrolide antibiotic | |
| Source of phytochemicals or plant Extracts | Calcarisporium arbuscular | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | DUSP1 | |
| Gene or Protein evidence | Real-time PCR and western blot analyses further demonstrated that aurovertin B could dramatically increase mRNA and protein expression levels of DUSP1 in MDA-MB-231 cells but not in MCF10A cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | Furthermore, the present study also revealed that aurovertin B induced apoptosis was due to regulation of ATP synthase activity rather than changes in gene expression. | |
| PubChem ID | 444853 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |