| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1159 | |
| Phytochemical name or plant extracts | Aucubin | |
| PMID | 28839362 | |
| Literature evidence | SUMMARY: Amongst the parts of Plantago major, seeds exhibited the greatest antiproliferative activity against MCF-7, MDA-MB-231, HeLaS3, A549, and KB cell lines as well as the highest inhibition on TNF-α, IL-1β, IL-6, and IFN-γ productionThe roots, which were commonly discarded, exhibited comparable antiproliferative and cytokines inhibition activities to those of leaves and petiolesUrsolic acid, a chemical compound of Plantago major, exhibited stronger activities than oleanolic acid and aucubinThe seeds are being proposed as the main source for further development of anticancer and anti inflammatory products, whereas the roots could be included in the preparation of Plantago major derived products with respect to anti inflammatory. | |
| IUPAC name | (2S,3R,4S,5S,6R)-2-[[(1S,4aR,5S,7aS)-5-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Monoterpenoid | |
| Source of phytochemicals or plant Extracts | Plantago media | |
| Geographical availability | Albania, Altay, Amur, Austria, Baltic States, Belarus, Belgium, Bulgaria, Buryatiya, Central European Rus, Chita, Czechoslovakia, Denmark, East European Russia, Finland, France, Germany, Great Britain, Greece, Hungary, Iran, Iraq, Irkutsk, Italy, Kazakhstan, Khabarovsk, Kirgizstan, Krasnoyarsk, Krym, Kuril Is., Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Poland, Primorye, Romania, Sakhalin, South European Russi, Spain, Sweden, Switzerland, Turkey, Tuva, Ukraine, West Siberia, Yakutskiya, Yugoslavia | |
| Plant parts | Root and Seeds | |
| Other cancers | Breast cancer, Cervical cancer, Lung cancer, Nasopharynx cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 602.66±47.40 µg/ml against MCF-7 966.98±17.84 µg/ml against MDA‑MB‑231 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HeLaS3, A549, and KB | |
| Additional information | NA | |
| PubChem ID | 91458 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:685411-1 | |
| Safety | NA |