| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-909 | |
| Phytochemical name or plant extracts | Artonin E | |
| PMID | 28356713 | |
| Literature evidence | In all, Artonin E stood high as a potential agent in the treatment of breast cancer. | |
| IUPAC name | 5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)-2-(2,4,5-trihydroxyphenyl)pyrano[2,3-h]chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Artocarpus elasticus | |
| Geographical availability | Borneo, Jawa, Lesser Sunda Is., Malaya, Myanmar, Philippines, Sumatera, Thailand | |
| Plant parts | Stem | |
| Other cancers | Breast cancer, Ovarian cancer, Ileocecal cancer | |
| Target gene or protein | p21, Cyclin D, cyt-c, Bax, Caspase 7, Caspase 9, MAPK | |
| Gene or Protein evidence | Gene and protein expression studies revealed significant upregulation of cytochrome c, Bax, caspases 7 and 9, and p21 in Artonin E-treated MCF-7 cells, while MAPK and cyclin D were downregulated. | |
| Target pathways | Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells. | |
| IC50 | 6.9 µM against MCF-7 | |
| Potency | In all, Artonin E showed the potential as a promising candidate to combat the aggressive triple negative breast cancer. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, 1A9, HCT-8 | |
| Additional information | Artonin E was seen to induce the activation of both extrinsic and intrinsic caspases initiators of apoptosis. It also enhanced the release of total reactive oxygen species which polarized the mitochondrial membrane, compounding the release of cytochrome c. Gene expression studies revealed the upregulation of TNF-related apoptosis inducing ligand and proapoptotic genes with down regulation of anti-apoptotic genes and proteins. | |
| PubChem ID | 5481962 | |
| Additional PMIDs | 28771532 15165133 28356713 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:850378-1 | |
| Safety | NA |