| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-910 | |
| Phytochemical name or plant extracts | Artocarpin | |
| PMID | 20544395 | |
| Literature evidence | Author information: (1)Stem Cell and Cancer Institute, Jalan Ahmad Yani no. 2, Pulomas, Jakarta, 13210, Indonesia. tangkearung@agr.kyushu-u.ac.jp In our screening projects for anticancer agents from natural resources, artocarpin [6-(3-methyl-1-butenyl)-5,2',4'-trihydroxy-3-isoprenyl-7-methoxyflavone] isolated from wood of jack fruit (Artocarpus heterophyllus) showed potent cytotoxic activity on human T47D breast cancer cells. | |
| IUPAC name | 2-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-[(E)-3-methylbut-1-enyl]-3-(3-methylbut-2-enyl)chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Artocarpus heterophyllus | |
| Geographical availability | India | |
| Plant parts | Wood | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 8, Caspase 10 | |
| Gene or Protein evidence | Artocarpin induced activation of caspase 8 and 10 as indicated by stronger signal intensity of cleaved-caspase 8 and weaker signal intensity of caspase 10 markers detected after artocarpin treatment. | |
| Target pathways | NA | |
| IC50 | 12.6 μM against T47D | |
| Potency | All together, these data indicated that artocarpin induced apoptosis in T47D cells possibly via an extrinsic pathway. | |
| Cell line/ mice model | T47D | |
| Additional information | These results showed that artocarpin caused a reduction of cell viability in a concentration-dependent manner and an alteration of cell and nuclear morphology. Moreover, the percentage of the sub-G1 phase formation was elevated dose-dependently. | |
| PubChem ID | 5458461 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:850389-1 | |
| Safety | NA |