| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2006 | |
| Phytochemical name or plant extracts | Artichoke Polyphenols | |
| PMID | 31998443 | |
| Literature evidence | Combined treatment of several natural polyphenols and chemotherapeutic agents is more effective comparing to the drug alone in inhibiting cancer cell growth. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Polyphenol | |
| Source of phytochemicals or plant Extracts | Cynara cardunculus | |
| Geographical availability | Albania, Algeria, Baleares, Canary Is., France, Italy, Libya, Madeira, Morocco, Portugal, Sicilia, Spain, Tunisia, Yugoslavia | |
| Plant parts | Edible part | |
| Other cancers | Breast cancer | |
| Target gene or protein | FEN1 | |
| Gene or Protein evidence | Our data shows that AEs/PTX reduced cell proliferation by increasing DNA damage response (DDR) mediated by Flap endonuclease 1 (FEN1) downregulation that results into enhanced breast cancer cell sensitivity to chemotherapeutic drugs. | |
| Target pathways | ROS/Nrf2 and p-ERK pathways are two molecular mechanisms involved in the synergistic effect of AEs plus PTX treatment. | |
| IC50 | NA | |
| Potency | Our results suggest the use of artichoke polyphenols as ROS-mediated sensitizers of chemotherapy paving the way for innovative and promising natural compound-based therapeutic strategies in oncology. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | We employed breast cancer cell lines to assess the potential synergistic effect of a combined treatment of AEs/paclitaxel (PTX) or AEs/adriamycin (ADR) and to determine the underlying mechanisms correlated to this potential therapeutic approach. To highlight the role of ROS herein, we report that the addition of antioxidant N-acetylcysteine (NAC) significantly decreased the antiproliferative effect of the combined treatment. A combined therapy could be able to reduce the dose of chemotherapeutic drugs, minimizing toxicity and side effects. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:200876-1 | |
| Safety | NA |