| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1908 | |
| Phytochemical name or plant extracts | Artemisinic acid | |
| PMID | 28784534 | |
| Literature evidence | Furthermore, results showed that A. herba alba possess high total antioxidant activity (Total antioxidant activity=423mg gallic acid equivalent/g dry weight), strong potential anticancer capacity against MCF-7 breast cancer and HeLa human cervical cell lines (IC50 of 15 and 70μg/ml, respectively), and moderate antibacterial activity against S. aureus, B. thurigiensis and A. hydrophila. | |
| IUPAC name | 2-[(1R,4R,4aS,8aR)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl]prop-2-enoic acid | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpenoid | |
| Source of phytochemicals or plant Extracts | Artemisia herba alba | |
| Geographical availability | France, Spain | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, HeLa | |
| Additional information | Artemisinic acid also reduced the expression of the adipogenesis-associated genes glucose transporter-4 and vascular endothelial growth factor. In addition to the interference of artemisinic acid with adipogenesis, artemisinic acid significantly attenuated tumor necrosis factor-α-induced secretion of interleukin-6 by undifferentiated hAMSCs, thus influencing insulin resistance and the inflammatory state characterizing obesity. | |
| PubChem ID | 10922465 | |
| Additional PMIDs | 22396222 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:179584-1 | |
| Safety | NA |