| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1331 | |
| Phytochemical name or plant extracts | Artemisia princeps extract | |
| PMID | 18225547 | |
| Literature evidence | The ability of A. princeps smoke and water extracts to induce apoptosis was evaluated in human breast cancer MCF-7 cells in vitro. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Smoke and water soluble extract. | |
| Source of phytochemicals or plant Extracts | Artemisia princeps | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Inner Mongolia, Japan, Manchuria, Ogasawara-shoto, Taiwan | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, Caspase 3, Caspase 8, Caspase 9 | |
| Gene or Protein evidence | Activation of caspases, changes in membrane potential, and BCL-2 expression were determined by flow cytometry. Induction of apoptosis was associated with activation of caspases 3, 8 and 9, depolarization of the mitochondrial membrane potential and down-regulation of BCL-2 expression. | |
| Target pathways | A. princeps smoke and water soluble extracts induce apoptosis via the mitochondrial pathway. | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:179985-1 | |
| Safety | NA |