| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-205 | |
| Phytochemical name or plant extracts | Artemisia absinthium extract | |
| PMID | 22311047 | |
| Literature evidence | Artemisia absinthium (AA): a novel potential complementary and alternative medicine for breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Artemisia absinthium | |
| Geographical availability | Afghanistan, Albania, Algeria, Altay, Austria, Baltic States, Belarus, Belgium, Bulgaria, Buryatiya, Central European Rus, China Southeast, Czechoslovakia, Denmark, East European Russia, Egypt, France, Germany, Greece, Hungary, Iceland, Iran, Iraq, Irkutsk, Italy, Kazakhstan, Kirgizstan, Krasnoyarsk, Kriti, Krym, Lebanon-Syria, Libya, Morocco, Netherlands, North Caucasus, North European Russi, Northwest European R, Pakistan, Poland, Portugal, Romania, South European Russi, Spain, Sweden, Switzerland, Tadzhikistan, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, West Himalaya, West Siberia, Western Sahara, Yugoslavia | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 7, Bad, Bcl-2 | |
| Gene or Protein evidence | Treatment with 25 μg/mL AA resulted in activation of caspase-7 and upregulation of Bad in MCF-7 cells, while exposure to 20 μg/mL AA induced upregulation of Bcl-2 protein in a time-dependent response in MDA-MB-231 cells. | |
| Target pathways | MEK/ERK pathway | |
| IC50 | NA | |
| Potency | Treatment with 25 μg/mL AA resulted in activation of caspase-7 and upregulation of Bad in MCF-7 cells, while exposure to 20 μg/mL AA induced upregulation of Bcl-2 protein in a time-dependent response in MDA-MB-231 cells. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | These results suggest that AA-induced anti-proliferative effects on human breast cancer cells could possibly trigger apoptosis in both cell lines through the modulation of Bcl-2 family proteins and the MEK/ERK pathway. | |
| PubChem ID | NA | |
| Additional PMIDs | 32988347 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:300106-2 | |
| Safety | NA |