| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-908 | |
| Phytochemical name or plant extracts | Artelastin | |
| PMID | 15878357 | |
| Literature evidence | Artelastin, a novel prenylated flavone, previously isolated from the wood bark of Artocarpus elasticus, was evaluated for its capacity to inhibit the growth of fifty-two human tumor cell lines, representing nine different tumor types. | |
| IUPAC name | 3,8,10-trihydroxy-9,11-bis(3-methylbut-2-enyl)-6-(2-methylprop-1-enyl)-6H-chromeno[4,3-b]chromen-7-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Artocarpus elasticus | |
| Geographical availability | Borneo, Jawa, Lesser Sunda Is., Malaya, Myanmar, Philippines, Sumatera, Thailand | |
| Plant parts | Wood Bark | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Studies to elucidate the basis of the growth inhibitory activity of artelastin were performed in the MCF-7 human breast cancer cell line (GI50 = 6.0 microM). | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Furthermore, artelastin acts as a cytotoxic rather than a cytostatic compound. Artelastin is a cytotoxic prenylated flavone that disturbs microtubules and interferes with DNA replication in MCF-7 human breast cancer cells. | |
| PubChem ID | 399488 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:850378-1 | |
| Safety | NA |