| Geographical availability |
Alabama, Arkansas, Connecticut, Delaware, District of Columbia, Florida, Georgia, Illinois, Indiana, Iowa, Kentucky, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, New Brunswick, New Hampshire, New Jersey, New York, Newfoundland, North Carolina, Nova Scotia, Ohio, Ontario, Pennsylvania, Prince Edward I., Québec, Rhode I., South Carolina, Tennessee, Vermont, Virginia, West Virginia, Wisconsin |
| Additional information |
An extract from berries of Aronia melanocarpa modulates the generation of superoxide anion radicals in blood platelets from breast cancer patients.
Our results suggest that the Aronia extract supplementation in breast cancer patients has a beneficial effect on thiols concentration in plasma.
Plasma, as reported in this work, could be used as an experimental model to evaluate the beneficial action of plant supplements, including phenolic extracts on thiols or other molecules during different phases of treatment.
The extract from A.
melanocarpa seems to be also useful as an antioxidant in patients with breast cancer.
In a model system in vitro we also observed that the extract from berries of A.
melanocarpa (50 µg/ml, 5 min, 37°C) due to antioxidant action, significantly reduced the oxidative/nitrative stress (measured by thiol groups and 3-nitrotyrosine) in platelets, not only from the healthy group, but also from patients with benign breast diseases and in patients with invasive breast cancer.
Considering the data presented in this study, we have demonstrated the protective role of the extract from A.
melanocarpa in patients with breast cancer in vitro. |