Phytochemical Name : Arnicolide D

Properties Information
PhytoCAT-ID PhytoCAT-1722
Phytochemical name or plant extracts Arnicolide D
PMID 32669950
Literature evidence Based on our findings, AD is a promising candidate for development as an adjunctive therapeutic drug for TNBC. © The author(s).
IUPAC name [(1S,3aR,5R,5aR,8aR,9S,9aR)-1,5,8a-trimethyl-2,8-dioxo-3a,4,5,5a,9,9a-hexahydro-1H-azuleno[6,5-b]furan-9-yl] 2-methylprop-2-enoate
Phytochemicals’ class or type of plant extracts Sesquiterpene lactone
Source of phytochemicals or plant Extracts Centipeda minima
Geographical availability Amur, Andaman Is., Assam, Bangladesh, Borneo, Cambodia, China North-Central, China South-Central, China Southeast, East Himalaya, Fiji, Hainan, India, Inner Mongolia, Japan, Jawa, Khabarovsk, Korea, Laos, Lesser Sunda Is., Malaya, Manchuria, Myanmar, Nansei-shoto, Nepal, New Caledonia, New Guinea, New South Wales, New Zealand North, New Zealand South, Northern Territory, Pakistan, Philippines, Primorye, Qinghai, Queensland, Samoa, Society Is., South Australia, Sri Lanka, Taiwan, Thailand, Tibet, Tonga, Vanuatu, Victoria, Vietnam, Western Australia, Xinjiang
Plant parts NA
Other cancers Breast cancer
Target gene or protein NA
Gene or Protein evidence NA
Target pathways Akt/mTOR and STAT3 signaling pathways
IC50 At 24h, 48h, 72h: 12.04 μM, 5.211 μM, 3.258 μM against MDA-MB-231 respectively 9.507 μM, 3.405 μM, 2.515 μM against MDA-MB-468 respectively 15.19 μM, 3.405 μM, 8.909 μM against MCF-7 respectively
Potency Based on our findings, AD is a promising candidate for development as an adjunctive therapeutic drug for TNBC.
Cell line/ mice model MDA-MB-231 xenograft mouse model, MDA-MB-231, MDA-MB-468
Additional information  NA
PubChem ID 182199
Additional PMIDs NA
Additional sources of information https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:191968-1
Safety NA