| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-984 | |
| Phytochemical name or plant extracts | Aristolochia foetida Kunth extract | |
| PMID | 34867010 | |
| Literature evidence | Higher concentrations of DSE and DLE are required to induce a cytotoxic effect in healthy mammary epithelial cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Dichloromethane extract | |
| Source of phytochemicals or plant Extracts | Aristolochia foetida | |
| Geographical availability | Mexico Central, Mexico Northeast, Mexico Southwest | |
| Plant parts | Leaves and stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | The cytotoxicity activity of the dichloromethane extract from the stems (DSE) showed IC50 values of 45.9 μg/mL and the dichloromethane extract of the leaves (DLE) showed IC50 values of 47.3 μg/mL. | |
| Potency | DSE and DLE induced a loss in mitochondrial membrane potential (ΔΨm) and can cause cell death by apoptosis through the intrinsic pathway in the MCF-7 cell line. DSE and DLE are cytotoxic in cancer cells and cause late apoptosis. Higher concentrations of DSE and DLE are required to induce a cytotoxic effect in healthy mammary epithelial cells. This is the first report of the dichloromethane extract of A. foetida Kunth that induces late apoptosis in MCF-7 cancer cells and may be a candidate for pharmacological study against breast cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | The results showed a significant reduction in cell viability of the MCF-7 (breast cancer) cell line caused by organic extracts in a dose-dependent manner. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:92938-1 | |
| Safety | NA |