| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1581 | |
| Phytochemical name or plant extracts | Arachidonic acid | |
| PMID | 17998642 | |
| Literature evidence | Investigations in our laboratory have focused on the mechanism of activity of variety of anticancer and antioxidant agents, namely, Eugenol, (EU), Ellagic acid (EA), Triphala (TPL), Tocopherol Succinate (TOS) and Arachidonic acid on normal and cancer cells with view to design effective protocols in practical radioprotection and cancer radiotherapy. | |
| IUPAC name | (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid | |
| Phytochemicals’ class or type of plant extracts | Essential fatty acid | |
| Source of phytochemicals or plant Extracts | Staphisagria macrosperma | |
| Geographical availability | Albania, Algeria, Baleares, Corse, Cyprus, East Aegean Is., France, Greece, Italy, Kriti, Lebanon-Syria, Morocco, Portugal, Sardegna, Sicilia, Spain, Tunisia, Turkey, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Cervical cancer, Breast cancer, Colon cancer | |
| Target gene or protein | p38, ER, TP53, Ki67 | |
| Gene or Protein evidence | Arachidonic acid stimulates cell adhesion by activating α2β1 integrins in a process that depends on protein kinases, including p38 mitogen activated protein kinase. Results demonstrated that diets with higher concentration of omega-6 PUFAs induced an increment of linoleic and arachidonic acid on tumor cell membranes increasing ROS liberation, 12(S)-HHT generation, TP53, Ki67 expression and cell proliferation. In the case of arachidonic acid (the reference fatty acid), this decrease was associated with a slight cleavage of the native 67 KDa estrogen receptor (ER) into 50 and 25-30 KDa peptides as demonstrated by sequential labeling of high-salt cell extracts with 3H-tamoxifen aziridine, specific immunoadsorption with H-222 anti-ER monoclonal antibody, SDS-PAGE and fluorography. | |
| Target pathways | Arachidonic acid promotes migration and invasion through a PI3K/Akt-dependent pathway in MDA-MB-231 breast cancer cells. | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | HeLa, MCF-7, MDA-MB-231, HT-29 | |
| Additional information | Arachidonic acid induces ER stress and apoptosis in HT-29 human colon cancer cells. | |
| PubChem ID | 444899 | |
| Additional PMIDs | 33209199 23747687 30230828 12470437 22322480 24402873 2265453 1460605 9137475 14659342 12550055 12694631 12086406 15138577 15860436 19931412 6422115 25712053 2503244 3609105 34004336 34486791 8058522 15741054 17052999 25213948 25448730 29550515 30830383 31663148 32588470 34500308 34579131 12401880 21241168 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60456584-2 | |
| Safety | NA |