| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-250 | |
| Phytochemical name or plant extracts | Arachidin-1 | |
| PMID | 35163062 | |
| Literature evidence | Investigating alternative therapies to increase survival rates for this disease is essential. | |
| IUPAC name | 5-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-2-[(E)-3-methylbut-1-enyl]benzene-1,3-diol | |
| Phytochemicals’ class or type of plant extracts | Stilbenoid | |
| Source of phytochemicals or plant Extracts | Arachis hypogaea | |
| Geographical availability | Bolivia | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 9, PARP, Survivin | |
| Gene or Protein evidence | Furthermore, A-1 induced caspase-dependent apoptosis through the intrinsic pathway by activating caspase-9 and PARP cleavage, and inhibiting survivin. | |
| Target pathways | NA | |
| IC50 | For 24h, 48h and 72h: 2.68 µM against MDA-MB-231, 7.82 µM against MDA-MB-231, 2.51 µM against MDA-MB-231 11.95 µM against MDA-MB-436, 6.20 µM against MDA-MB-436, 2.09 µM against MDA-MB-436 | |
| Potency | In conclusion, A-1 merits further research as a potential lead molecule for the treatment of TNBC. | |
| Cell line/ mice model | MDA-MB-231, MDA-MB-435, MCF-10A | |
| Additional information | A-1 did not show significant cytotoxicity in the non-cancerous cell line MCF-10A. While A-1 blocked cell division in G2-M phases in the TNBC cells, it did not affect cell division in MCF-10A cells. | |
| PubChem ID | 11220670 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:318562-2 | |
| Safety | A-1 did not show significant cytotoxicity in the non-cancerous cell line MCF-10A. |