| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1244 | |
| Phytochemical name or plant extracts | Antroquinonol (AQ) | |
| PMID | 33371814 | |
| Literature evidence | In conclusion, our results displayed an overall pattern that AQ and 4-AAQB possess potential anti-inflammatory and antitumorigenic functions in MCF-7 breast cancer cells and warranted further in vivo pre-clinical and clinical studies to explore their anticancer properties. | |
| IUPAC name | (4R,5R,6R)-4-hydroxy-2,3-dimethoxy-6-methyl-5-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]cyclohex-2-en-1-one | |
| Phytochemicals’ class or type of plant extracts | Quinone | |
| Source of phytochemicals or plant Extracts | Antrodia camphorata | |
| Geographical availability | Taiwan | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Liver cancer, Prostate cancer | |
| Target gene or protein | IL-10, PTGS2, IL-6 | |
| Gene or Protein evidence | AQ inhibited two of them (IL-10 and PTGS2). | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | In conclusion, our results displayed an overall pattern that AQ and 4-AAQB possess potential anti-inflammatory and antitumorigenic functions in MCF-7 breast cancer cells and warranted further in vivo pre-clinical and clinical studies to explore their anticancer properties. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, Hep3B, HepG2, DU-145, LNCaP | |
| Additional information | Antroquinonol has been used in trials studying the treatment of Hyperlipidemias, Non-small Cell Lung Cancer, and Non-small Cell Lung Cancer Stage IV. | |
| PubChem ID | 24875259 | |
| Additional PMIDs | 17932820 | |
| Additional sources of information | https://www.drugbank.ca/drugs/DB12326 | |
| Safety | NA |