| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1901 | |
| Phytochemical name or plant extracts | Antrodia cinnamomea extract | |
| PMID | 28602756 | |
| Literature evidence | We also established an association between the CSC-inhibitory effect of A. cinnamomea and significant downregulation of several microRNAs and cancer stemness expression levels in brain and breast CSCs. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethyl acetate extract | |
| Source of phytochemicals or plant Extracts | Antrodia cinnamomea | |
| Geographical availability | NA | |
| Plant parts | Fruiting body | |
| Other cancers | Breast cancer, Glioma, Leukemia, Lung cancer , Liver cancer, Colorectal cancer | |
| Target gene or protein | skp2 | |
| Gene or Protein evidence | Suppresses the mRNA expression of skp2 (S-phase kinase-associated protein 2) by increasing the expressions of miR-21-5p, miR-26-5p, and miR-30-5p (MCF-7 and tamoxifen-resistant MCF-7 cells) | |
| Target pathways | PI3K/Akt/mTOR signaling pathway inducing apoptosis and attenuated T47D BC cell, it can suppress the mRNA expression of skp2 (S-phase kinase-associated protein 2) pathway. | |
| IC50 | NA | |
| Potency | We demonstrate the putative role of A. cinnamomea as an effective ethnopharmacologic therapeutic agent for cancer treatment. | |
| Cell line/ mice model | GBM 8401, A549, THP-1, HepG2, SW620, MDA-MB-231, HS68, 3T3, BALB/c , tamoxifen-resistant MCF-7, T47D BC cell. | |
| Additional information | Downregulates a panel of onco-microRNAs including hsa-miR-216a, hsa-let-7e, hsamiR-221, hsa-miR-302c and hsa-miR-21 Increases the cell antioxidant ability by improving the activity of superoxide dismutase (SOD) and decreases Dox-induced ROS, has synergistic effects with Dox against MCF-7 breast cancer cells suppresses the mRNA expression of skp2 (S-phase kinase-associated protein 2) by increasing the expressions of miR-21-5p, miR-26-5p, and miR-30-5p (MCF-7 and tamoxifen-resistant MCF-7 cells) | |
| PubChem ID | NA | |
| Additional PMIDs | 25542609 28160860 29743060 25658913 32629666 | |
| Additional sources of information | NA | |
| Safety | NA |