| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1208 | |
| Phytochemical name or plant extracts | Anthocyanin | |
| PMID | 24996346 | |
| Literature evidence | Fractionation of peach BY00P6653 extracts gave 4 fractions, with fraction F-I (caffeic acid derivatives) showing a strong activity against MDA-MB-435 followed by fraction F-II (anthocyanins). | |
| IUPAC name | 2-phenylchromenylium | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Vitis coignetiae Pulliat | |
| Geographical availability | Japan, Korea, Kuril Is., Sakhalin | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Colon cancer, Lung cancer, Stomach cancer | |
| Target gene or protein | TNF-α, NF-kappaB, COX-2, C-myc, MMP2, MMP9, ICAM-1, VEGF | |
| Gene or Protein evidence | AIM suppressed the TNF-alpha effects on the NF-kappaB-regulated proteins involved in cancer cell proliferation (COX-2, C-myc), invasion, and angiogenesis (MMP-2, MMP9, ICAM-1, and VEGF). | |
| Target pathways | NF-kappaB pathway, PI3K-Akt pathway | |
| IC50 | 25 µg/mL against MCF-7 | |
| Potency | This study demonstrates that the anthocyanins isolated from the fruits of Vitis coignetiae Pulliat acts as an inhibitor of TNF-alpha induced NF-kappaB activation, and subsequent downstream molecules involved in cancer proliferation, invasion, adhesion, angiogenesis, and thus have anti-metastatic activities in MCF-7 breast cancer cells. | |
| Cell line/ mice model | MDA-MB-435, HCT-116, MCF-7, NCI-H460, SF-268, AGS | |
| Additional information | NA | |
| PubChem ID | 145858 | |
| Additional PMIDs | 19166352 23203096 27234523 29382057 32420359 23937661 23333825 31621765 33051045 18435529 32698737 19271318 19212682 23712096 28284186 30070707 31448633 27016122 15680311 16277432 16139847 12925310 21034468 30876970 24204712 20170107 32455624 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:68634-1 | |
| Safety | NA |