| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1372 | |
| Phytochemical name or plant extracts | Antcin-A | |
| PMID | 31185503 | |
| Literature evidence | Further investigations revealed that ATA-mediated induction of miR-200c is associated with transcriptional activation of p53, as confirmed by the fact that ATA failed to induce miR-200c or suppress ZEB1 activity in p53 inhibited cells. | |
| IUPAC name | (2S,6R)-2-methyl-3-methylidene-6-[(4S,5S,10S,13R,14R,17R)-4,10,13-trimethyl-3,11-dioxo-2,4,5,6,7,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]heptanoic acid | |
| Phytochemicals’ class or type of plant extracts | Steroid | |
| Source of phytochemicals or plant Extracts | Antrodia cinnamomea | |
| Geographical availability | Taiwan | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, E-cadherin, occludin, N-cadherin, Vimentin, ZEB1 | |
| Gene or Protein evidence | Treatment with ATA significantly blocked EMT processes, as evidenced by upregulation of epithelial markers (E-cadherin and occludin) and downregulation of mesenchymal markers (N-cadherin and vimentin) via suppression of their transcriptional repressor ZEB1. Further investigations revealed that ATA-mediated induction of miR-200c is associated with transcriptional activation of p53. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 and MDA-MB-231 | |
| Additional information | Further investigations revealed that ATA-mediated induction of miR-200c is associated with transcriptional activation of p53, as confirmed by the fact that ATA failed to induce miR-200c or suppress ZEB1 activity in p53 inhibited cells. | |
| PubChem ID | 44424392 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |