| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1340 | |
| Phytochemical name or plant extracts | Anoectochilus formosanus extract | |
| PMID | 15591790 | |
| Literature evidence | Plant extracts of A. formosanus were observed to induce apoptosis of MCF-7 cells as evidenced by cell-morphological changes, an early redistribution of plasma membrane phosphatidylserine, and DNA content distribution studies. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethyl acetate extract | |
| Source of phytochemicals or plant Extracts | Anoectochilus formosanus Hayata | |
| Geographical availability | China Southeast, Nansei-shoto, Taiwan | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer | |
| Target gene or protein | FasL, FAST, phospholipase C, kinase C, the type 1 inositol 1,4,5-triphosphate receptor (IP3R-1), c-Jun N-terminal kinase (JNK), c-Jun | |
| Gene or Protein evidence | In this study, FasL protein levels were significantly increased and the mRNA expression level of FAST was upregulated upon EA treatment of MCF-7 cells, Mechanism II involves several proteins, including phospholipase C, protein kinase C, the type 1 inositol 1,4,5-triphosphate receptor (IP3R-1), c-Jun N-terminal kinase (JNK), and c-Jun, which have been reported to play important roles in apoptosis. | |
| Target pathways | Apoptotic signaling pathways | |
| IC50 | 0.08 mg/ml against MCF-7 | |
| Potency | Flow cytometry showed that the Fas ligand protein was overexpressed in EA-treated MCF-7 cells. Functional genomic studies indicated that specific genes related to cytoskeleton rearrangement, apoptotic signal transduction, and various transcription factors were differentially regulated in EA-treated MCF-7 cells. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 15067226 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:616574-1 | |
| Safety | NA |