| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-959 | |
| Phytochemical name or plant extracts | Annonacin | |
| PMID | 11534761 | |
| Literature evidence | Annomocherin, annonacin and annomontacin: a novel and two known bioactive mono-tetrahydrofuran annonaceous acetogenins from Annona cherimolia seeds. | |
| IUPAC name | (2S)-2-methyl-4-[(2R,8R,13R)-2,8,13-trihydroxy-13-[(2R,5R)-5-[(1R)-1-hydroxytridecyl]oxolan-2-yl]tridecyl]-2H-furan-5-one | |
| Phytochemicals’ class or type of plant extracts | Mono-tetrahydrofuran (THF) annonaceous acetogenins | |
| Source of phytochemicals or plant Extracts | Annona cherimolia | |
| Geographical availability | Bolivia, Colombia, Ecuador, Peru | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer, Kidney cancer | |
| Target gene or protein | Cyclin D1, Bcl-2, HIF-1 | |
| Gene or Protein evidence | Moreover, annonacin attenuated MCF-7 xenograft tumor growth while inhibiting ERα, cyclin D1 and Bcl-2 protein expressions in nude mice. In T47D cells, pawpaw CE and the acetogenins 10-hydroxyglaucanetin (1), annonacin (2), and annonacin A (3) inhibited hypoxia-induced HIF-1 activation with IC(50) values of 0.02 microg/mL, 12 nM, 13 nM, and 31 nM, respectively. | |
| Target pathways | NA | |
| IC50 | 12 nM against T47D | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 xenografts in nude mice, MDA-MB-231, MCF-7, T47D | |
| Additional information | Moreover, annonacin decreased phosphorylation of ERK1/2, JNK and STAT3. | |
| PubChem ID | 354398 | |
| Additional PMIDs | 21840388 30105068 24868866 11534761 20423107 7764028 1791482 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:927235-1 | |
| Safety | In brine shrimp lethality test (BST), 1-3 exhibited cytotoxicity. |