| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-73 | |
| Phytochemical name or plant extracts | Annona muricata extract | |
| PMID | 27558166 | |
| Literature evidence | Then, based on the IC50 profile from the anti-proliferative assay, further downward assays such as cell cycle analysis, Annexin V/FITC, AO/PI, migration, invasion, and wound healing assay were performed only with the most potent leaf aqueous extract (B1 AMCE) on 4 T1 breast cancer cell line to investigate its anti-cancer effect. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Annona muricata | |
| Geographical availability | Belize, Bolivia, Colombia, Costa Rica, Ecuador, French Guiana, Guatemala, Guyana, Honduras, Mexico Southeast, Nicaragua, Panamá, Peru, Suriname, Venezuela | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | AKT, MAPK, NF-κB,cyclin D1, Aromatase, EGFR | |
| Gene or Protein evidence | The antiproliferative influence is produced through EGFR-mediated signaling pathways, which include AKT, MAPK, NF-κB, and cyclin D1 inhibition. The suggested strategy provides a reliable means of prospecting in-silico screening of natural products databases in the search for new dug leads as aromatase inhibitors. | |
| Target pathways | EGFR-mediated signaling pathways | |
| IC50 | 220 μg/mL against MCF-7 350 μg/mL against MDA-MB231, 250 μg/mL against 4T1 | |
| Potency | The selected B1 AMCE reduced the tumor's size and weight, showed anti-metastatic features, and induced apoptosis in vitro and in vivo of the 4 T1 cells. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, 4T1 | |
| Additional information | Furthermore, it decreased the level of nitric oxide and malondialdehyde in tumor while also increased the level of white blood cell, T-cell, and natural killer cell population. | |
| PubChem ID | NA | |
| Additional PMIDs | 27262333 28712058 30105068 29909120 34295188 34567146 22130377 7673936 27558166 33304106 33342779 33048613 33960623 21355237 25312150 30663427 34267553 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:14308-2 | |
| Safety | NA |