| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-961 | |
| Phytochemical name or plant extracts | Annona cherimola ethanolic leaf extract (AELE) | |
| PMID | 33187495 | |
| Literature evidence | Annona cherimola, popularly known as Cherimoya, is an edible natural fruit rich in phytochemical components and known to possess various biological activities. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Annona cherimola | |
| Geographical availability | Bolivia, Colombia, Ecuador, Peru | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2, p21, cyt-c | |
| Gene or Protein evidence | A significant upregulation of p21 and cytochrome c was observed, compared to control untreated cells. Moreover, a significant increase in the Bax /Bcl2 ratio revealed a Bax/Bcl2 dependent pathway for apoptosis induction | |
| Target pathways | mitochondrial apoptotic pathway | |
| IC50 | At 24h, 48h: 555.3 μg/mL against MDA-MB-231 , 390.2 μg/mL against MDA-MB-231 respectively | |
| Potency | All the data presented in our study suggest that AELE exhibits a selective anti-proliferative and pro-apoptotic effect on the chemo-resistant MDA-MB-231 breast cancer cells, providing evidence for the anti-tumor effects of A. cherimola. | |
| Cell line/ mice model | MDA-MB-231 and MCF-7 | |
| Additional information | The pro-apoptotic effect was confirmed by the increase in cellular and DNA fragmentation, flipping of the phosphatidylserine moiety to the outer leaflet, and the increase in Annexin V binding. The underlying molecular mechanism revealed the involvement of the mitochondrial pathway, as shown by alterations in mitochondrial permeability and the upregulation of cytochrome c expression. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:927235-1 | |
| Safety | NA |