| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-788 | |
| Phytochemical name or plant extracts | Angelica sinensis polysaccharide | |
| PMID | 26431878 | |
| Literature evidence | Thus, these results suggest that ASP would be a promising therapeutic agent for breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Polysaccharide | |
| Source of phytochemicals or plant Extracts | Angelica sinensis | |
| Geographical availability | China North-Central, China South-Central, Inner Mongolia | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | PARP, Bax, Bcl-2, Bcl-xL, Apaf1 | |
| Gene or Protein evidence | We found that ASP significantly affected the poly-ADP-ribose polymerase (PARP), Bcl-2 Associated X Protein (Bax), Bcl-2, Bcl-xL and apoptotic protease activating facter-1 (Apaf1) protein expression in a dose- and time-dependent manner. | |
| Target pathways | CREB signaling pathway | |
| IC50 | NA | |
| Potency | ASP has profound antitumor effect on T47D cells, probably by inducing apoptosis through CREB signaling pathway. Thus, these results suggest that ASP would be a promising therapeutic agent for breast cancer. | |
| Cell line/ mice model | T47D, nude mice xenograft model | |
| Additional information | In this study, we show that angelica sinensis polysaccharide induced apoptosis in breast cancer cells of T47D over-expressing the Cyclic AMP response element binding protein (CREB), inducing apoptosis-related signaling pathway activity. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77065778-1 | |
| Safety | NA |