| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1986 | |
| Phytochemical name or plant extracts | Andrographolide | |
| PMID | 34000264 | |
| Literature evidence | Network pharmacology-based evaluation of natural compounds with paclitaxel for the treatment of metastatic breast cancer. | |
| IUPAC name | (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Andrographis paniculata | |
| Geographical availability | Assam, Bangladesh, India, Nepal, Sri Lanka, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Heme oxygenase-1, MMP9, COX-2 | |
| Gene or Protein evidence | Induction of heme oxygenase-1 and inhibition of TPA-induced matrix metalloproteinase-9 expression by andrographolide in MCF-7 human breast cancer cells. he results indicated that Andro could significantly inhibit the proliferation of human breast cancers, and suppress COX-2 expression at both protein and mRNA levels. | |
| Target pathways | p300 signaling and VEGF pathway | |
| IC50 | NA | |
| Potency | This work demonstrated the potential anti-cancer effects of Andro, indicating that Andro could inhibit COX-2 expression through attenuating p300 HAT activity and suppress angiogenesis via VEGF pathway, and thereby could be developed as an antitumor agent for the treatment of breast cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Co-incubation of FEC only with AND results in deregulation of 10 genes causing death of breast cancer cells, decrease of liver toxicity and attenuation of organismal death. Most of the studies support the hypothesis that andrographolide supplementation stimulates immune system, so the observed effects migh in fact be secondary to the stimulation of defense reactions. As andrographolide is involved in regulation of inflammation, it is not surprising that it is also evaluated in inflammation-mediated diseases such as ulcerative colitis. The combination of Tan IIA and Andro showed significant synergistic effects on cancer cell apoptosis by promoting crosstalk between ROS and p53, providing a novel and effective combination that has the potential to be applied in clinical anticancer therapy. CAM assay results suggested that andrographolide (AND), SIL and TA increase the anti-angiogenic potential of Paclitaxel (PTX). Thus, natural compounds can be used to improve the anti-cancer potential of PTX. | |
| PubChem ID | 5318517 | |
| Additional PMIDs | 16789428 17234223 31728115 31983184 34430627 23615401 30314513 30668345 32048269 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:45226-1 | |
| Safety | NA |